| Intervention group (2 weeks IV + 4 weeks oral) | Standard group (6 weeks IV) |
---|---|---|
First 2 weeks | Ceftriaxone 4 g × 1 / cefotaxime 3 g × 4 + metronidazole 500 mg × 3 | Ceftriaxone 4 g × 1 / cefotaxime 3 g × 4 + metronidazole 500 mg × 3 |
Next 4 weeks | Oral amoxicillin 1 g × 4 + metronidazole 500 mg × 3 | Ceftriaxone 4 g × 1 / cefotaxime 3 g × 4 + metronidazoleb 500 mg × 3 |
In case of Streptococcal spp. with a minimal inhibitory concentration for penicillin ≥1 mg/L, beta-lactam allergy, non-susceptibility, interaction with other drugs, or development of drug fever. | a) Oral moxifloxacin 400 mg × 1 + metronidazole 500 mg × 3 b) Oral linezolid 600 mg × 2 + metronidazole 500 mg × 3 c) Oral clindamycin 600 mg × 4 | a) Meropenem 2 g × 3 b) Moxifloxacin 400 mg × 1 + metronidazole 500 mg × 3 c) Clindamycin 600 mx 4 |