Table 1 Inclusion and exclusion criteria for the MEDIMACS clinical trial

Inclusion criteria

 1. Equal or older than 18 years

 2. An established diagnosis of ACS based on clinical, electrocardiographic and laboratory criteria

 3. An intermediate (20–60% lumen stenosis) atherosclerotic lesion identified in a non-culprit coronary artery with diameter > 2.0 mm (target lesion) not undergoing percutaneous coronary intervention at the time of the revascularization procedure

 4. Willingness to modify his/her diet

 5. Able to follow up and answer questionnaires

Exclusion criteria

 1. Thrombolysis in Myocardial Infarction (TIMI) score < 3 in the culprit vessel (unsuccessful revascularization)

 2. Killip classification III/IV

 3. Active systemic infection, chronic inflammatory disease, periodontal disease or treatment with corticosteroids, antibiotics or immunomodulators within the past 3 months

 4. Renal insufficiency with glomerular filtration less than 30 mL/min

 5. Severe hepatic insufficiency (liver cirrhosis in Child B or C stages)

 6. Any comorbidity with life expectancy of less than 1 year