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Table 2 Operating characteristics of nine different scenarios

From: The design of a Bayesian adaptive clinical trial of tranexamic acid in severely injured children

Scenario Power Probability of stopping the entire trial at specific interim looks Probability of opening 45 mg/kg dose
Brain Torso Both 1000 1250 1500 1750 2000 Brain Torso Both
1 2.1% 2.2% 1.4% 0.3% 1.8% 2.5% 4.4% 91.0% 21.5% 20.6% 21.7%
2 94.9% 82.9% 64.4% 16.9% 22.5% 19.8% 15.9% 24.8% 73.9% 70.7% 63.9%
3 92.3% 64.6% 52.4% 10.1% 15.2% 15.9% 16.7% 42.1% 72.5% 65.0% 65.1%
4 97.0% 89.0% 73.1% 23.8% 27.8% 20.3% 14.3% 13.7% 79.3% 76.1% 68.7%
5 92.5% 5.0% 39.0% 2.1% 4.2% 5.6% 18.2% 69.9% 67.3% 35.5% 59.8%
6 4.4% 65.9% 30.5% 0.9% 2.4% 4.6% 5.4% 86.6% 30.4% 63.4% 56.4%
7 3.2% 61.0% 3.2% 0.9% 2.2% 4.2% 5.9% 86.9% 27.0% 57.7% 30.6%
8 90.6% 4.3% 5.3% 1.9% 4.0% 5.6% 11.4% 77.2% 64.7% 31.6% 34.7%
9 0.0% 71.4% 24.7% 3.5% 11.6% 18.6% 20.1% 46.1% 9.4% 53.0% 41.2%
  1. Italicized cells indicate the one-sided type I error rate in those scenarios. Bolded cells indicate the postulated scenario