Table 2 Comparison of clinical trial methodologies
Clinical trials/protocol | Albert et al. [6] | Bråten et al. [7] | Urquhart et al. (2021) |
|---|---|---|---|
Patient subgroup | |||
Participants with disc herniation and type 1 Modic changes | Participants with disc herniation and type 1 and 2 Modic changes | Participants with disc herniation—with and without type 1 and 2 Modic changes | |
Intervention | |||
Amoxicillin-clavulanate (500/125 mg) 100 days | Amoxicillin (750 mg) 3 months | Amoxicillin-clavulanate (500/125 mg) 3 months | |
Other treatments allowed | |||
No other treatment allowed during the 1 year trial period. | Usual care allowed Encouraged to limit non-steroidal anti-inflammatories | Usual care allowed Use of non-opioid analgesia and non-steroidal anti-inflammatories permitted | |