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Table 4 Fluid administration

From: PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial

Characteristic

0.9% saline

Balanced/buffered fluid

Difference (95% CI)

 

(n = )

(n = )

 

Number of crystalloid fluid boluses, median (IQR)

   

 Totala

   

 Prior to randomization

   

 During intervention phase

   

Crystalloid volume administered (mL/kg), median (IQR)

   

 Total fluid (bolus and maintenance)a

   

  Any crystalloid

   

  0.9% saline

   

  Balanced/buffered fluid

   

 Bolus fluid only

   

  Prior to randomization

   

  During intervention phase

   

  0.9% saline

   

  Balanced/buffered fluid

   

 Maintenance fluid only

   

  Any crystalloid

   

  0.9% saline

   

  Balanced/buffered fluid

   

  Other

   

Colloid volume administered (mL/kg), median (IQR)

   

 Albumin 4%/5%

   

 Other

   

Blood product volume administered (mL/kg), median (IQR)

   

 Red blood cells

   

 Platelets

   

 Plasma or cryoprecipitate

   

 Other

   

Fluid volume categoriesa, n (%)

   

 Total crystalloid (bolus and maintenance)

   

  <60 mL/kg

   

  60–100 mL/kg

   

  >100 mL/kg

   

 Bolus fluid only

   

  <60 mL/kg

   

  60–100 mL/kg

   

  >100 mL/kg

   

Protocol Adherence

   

 Received ≥75% of total crystalloid as randomized fluid type during intervention phase, n (%)

   
  1. aIncludes fluid administered prior to randomization and during the intervention phase