Deprescribing to reduce polypharmacy: study protocol for a randomised controlled trial assessing deprescribing of anticholinergic and sedative drugs in a cohort of frail older people living in the community

Table 3 Outcome measures and analysis

Outcome	Measure	Alternative hypothesis	Analysis
Drug burden change	Proportion ΔDBI ≥ 0.5	Intervention greater	χ² comparison of proportions
Emergency department visits	Proportion	Remain the same or decrease	χ² comparison of proportions
Unplanned hospital admissions	Proportion	Remain the same or decrease	χ² comparison of proportions
Admissions into aged residential care	HR	Remain the same or decrease	CRRA
Mortality	HR	Remain the same or decrease	CRRA

ΔDBI change in Drug Burden Index, WSR Wilcoxon signed-rank test, CRRA competing risk regression analyses, χ² chi-square

ISSN: 1745-6215