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Table 1 Patient-level data collected

From: A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial

Source (extraction method)

Data collected

Trauma registry

(automated extraction)

Date of presentation to the emergency department or hospital

Date of ICU admission

Age on day of admission

Gender

Race and ethnicity

Payer status

Elixhauser comorbidity index

Mechanism of injury

Injury Severity Score

Electronic health record (automated extraction)

Cigarette smoking status

Body mass index

Covid-19 status

Shock Index

All validated SpO2 values in ICU

Unvalidated SpO2 values (continuous, recorded up to every minute when available) in ICU

All PaO2 values in ICU

All FiO2 values in ICU

All PEEP values in ICU

All oxygen volume measurements in ICU

Date of discharge from ICU

Date of in-hospital death

Discharge disposition

Electronic health record (manual extraction)

Military status

Home supplemental oxygen use

Discharge GOS

Calculated outcomes

Supplemental Oxygen Free Day (SOFD) to day 28

Ventilator-free days to day 28 (VFD28)

Hospital-free days to day 90 (HFD90)

In-hospital mortality to day 90

Time to mortality to day 90

Time to room air (or FiO2=0.21)

Frequency of hypoxic episodes

Duration of hypoxic episode

Frequency of hyperoxic episodes

Duration of hyperoxic episodes

Total duration of time on normoxia protocol

Amount of supplemental oxygen administered (total estimated oxygen volume administered in ICU)

Duration of time on normoxia protocol target (time with SpO2 90-96% or receiving no supplemental oxygen while in ICU)

Proportion of participants receiving high levels of supplemental oxygen (FiO2 > 0.4 or more than 4LPM for more than 2 h while in ICU; excluding operating room time)

Duration of time receiving high levels of supplemental oxygen

Duration of time receiving no supplemental oxygen or FiO2 = 0.21

  1. Abbreviations: COVID-19 coronavirus disease 2019, FiO2 fraction of inspired oxygen, GOS Glasgow Outcome Scale, ICU intensive care unit; LPM liters per minute; PaO2 partial pressure of arterial oxygen, PEEP positive end expiratory pressure, SpO2 saturation of oxygen