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Fig. 1 | Trials

Fig. 1

From: Clinical effectiveness and safety of baricitinib for the treatment of juvenile idiopathic arthritis-associated uveitis or chronic anterior antinuclear antibody-positive uveitis: study protocol for an open-label, adalimumab active-controlled phase 3 clinical trial (JUVE-BRIGHT)

Fig. 1

Schematic of trial design. aPatients ≥6 to <12 years old assigned to baricitinib have the option of receiving the oral suspension or tablets. Patients >12 years old assigned to baricitinib will receive tablets. Patients assigned to adalimumab weighing <30 kg will receive 20 mg, and those ≥ 30 kg will receive 40 mg. bPatients receiving adalimumab who experience a treatment failure after at least 24 weeks of treatment may receive rescue therapy with baricitinib. Rescued patients will receive baricitinib for the remainder of the study. bDMARD, biologic disease-modifying antirheumatic drug; MTX-IR, inadequate response or intolerance to methotrexate; OLE, open-label extension

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Trials

ISSN: 1745-6215