From: Estimands in published protocols of randomised trials: urgent improvement needed
Question | Trials (n = 50)—no. (%) |
---|---|
Used term “estimand” | 0 (0%) |
Cited ICH E9(R1) Addendum | 0 (0%) |
Estimand attributes | |
Population | |
Stated | 0 (0%) |
Inferable | 32 (64%) |
Not inferable | 18 (36%) |
Treatment condition(s) | |
Stated | 0 (0%) |
Inferable | 40 (80%) |
Not inferable | 10 (20%) |
Outcome | |
Stated | 50 (100%) |
Inferable | 0 (0%) |
Not inferable | 0 (0%) |
Population-level summary measure | |
Stated | 0 (0%) |
Inferable | 33 (66%) |
Not inferable | 17 (34%) |
Handling of intercurrent event(s) | |
Stated | 0 (0%) |
Inferable | 20 (40%) |
Not inferable | 30 (60%) |
Overall estimand | |
Stated | 0 (0%) |
Inferable | 13 (26%) |
Not inferable | 37 (74%) |
Number of attributes not inferable | |
0 | 13 (26%) |
1 | 14 (28%) |
2 | 9 (18%) |
3 | 13 (26%) |
4 | 1 (2%) |
5 | 0 (0%) |