Table 1 DISC trial objectives

1

To investigate whether collagenase injection is not inferior to limited fasciectomy in the (impact of) correction of Dupuytren’s contracture of the hand at 1 year^a.

2

To investigate whether the (impact of) correction achieved after collagenase injection or surgical correction is maintained at 1 and 2 years^a.

3

To investigate the cost-effectiveness of collagenase injections compared to limited fasciectomy at 1 and 2 years after treatment (from the NHS and Personal Social Services perspectives).

4

To investigate if the remote measurement of active extension and flexion using photographs is as good as goniometric measurements in a clinic to determine recurrence (photography sub-study).

5

To explore patient’s experiences and preferences of the different treatments (qualitative sub-study).