Criteria | Constrained randomization method | ||
---|---|---|---|
Unconstrained/simple | Prognostic baseline characteristics | Principal components | |
11 prognostic characteristics c | |||
Number of constrained baseline characteristics that were balanced in all 1000 (100%) sampled allocations | 0 of 11 (0%) a | 2 of 11 (18%) | 2 of 11 (18%) |
Number of constrained baseline characteristics that were balanced in at least 950 (95%) sampled allocations | 6 of 11 (55%) | 10 of 11 (91%) | 7 of 11 (64%) |
Number of constrained baseline characteristics that were balanced in at least 900 (90%) sampled allocations | 8 of 11 (73%) | 10 of 11 (91%) | 9 of 11 (82%) |
Median (25th and 75th percentile) number of baseline characteristics that were balanced across the 1000 selected randomization schemes | 10 (9, 11) b | 11 (10, 11) | 10 (10, 11) |
29 baseline characteristics used in the principal component analysisd | |||
Number of constrained baseline characteristics that were balanced in all 1000 (100%) sampled allocations | 8 of 29 (28%) | 12 of 29 (41%) | 12 of 29 (41%) |
Number of constrained baseline characteristics that were balanced in at least 950 (95%) sampled allocations | 19 of 29 (66%) | 23 of 29 (79%) | 25 of 29 (86%) |
Number of constrained baseline characteristics that were balanced in at least 900 (90%) sampled allocations | 24 of 29 (83%) | 25 of 29 (86%) | 26 of 29 (90%) |
Median (25th and 75th percentile) number of baseline characteristics that were balanced across the 1000 selected randomization schemes | 27 (26, 28) | 28 (27, 28) | 28 (28, 29) |
All 156 available baseline characteristics | |||
Number of constrained baseline characteristics that were balanced in all 1000 (100%) sampled allocations | 41 of 156 (26%) | 46 of 156 (28%) | 55 of 156 (35%) |
Number of constrained baseline characteristics that were balanced in at least 950 (95%) sampled allocations | 104 of 156 (67%) | 115 of 156 (74%) | 118 of 156 (76%) |
Number of constrained baseline characteristics that were balanced in at least 900 (90%) sampled allocations | 125 of 156 (80%) | 132 of 156 (85%) | 134 of 156 (86%) |
Median (25th and 75th percentile) number of baseline characteristics that were balanced across the 1000 selected randomization schemes | 147 (142, 150) | 149 (146, 151) | 150 (147, 151) |