Table.2 The percentage of times each of the baseline characteristics was balanced across each of the 1000 randomizations schemes in the trial population
Baseline characteristic | Value | Constrained randomization method | ||
|---|---|---|---|---|
Unrestricted/simple | Prognostic baseline characteristics | Principal components | ||
Center size | Mean ± standard deviation | 32.9% | 41.8% | 38.7% |
Composite outcome of CV-related death and major CV-related hospitalization | Rate (per 100 person-year) | 32.5% | 36.2% | 33.5% |
Age (years) | Mean ± standard deviation | 95.3% | 99.8% | 99.2% |
< 65 | 97.8% | 99.7% | 99.9% | |
65 to 74 | 100.0% | 100.0% | 100.0% | |
75 to 84 | 100.0% | 100.0% | 100.0% | |
85 to 105 | 99.5% | 100.0% | 99.9% | |
Sex | Male | 100.0% | 100.0% | 100.0% |
Living in a rural area | Yes | 63.0% | 84.2% | 65.8% |
Etiology for end-stage kidney disease | Diabetes | 93.0% | 94.5% | 95.0% |
Glomerulonephritis/autoimmune diseases | 96.3% | 100.0% | 99.5% | |
Drug-induced nephropathy | 100.0% | 99.9% | 100.0% | |
Polycystic kidney disease | 100.0% | 100.0% | 100.0% | |
Renal vascular disease | 97.5% | 97.6% | 96.7% | |
Other | 88.3% | 91.9% | 91.6% | |
Race | Asian | 75.0% | 81.3% | 88.1% |
Black | 73.4% | 95.9% | 91.9% | |
White | 45.6% | 64.0% | 90.2% | |
Other | 56.6% | 65.7% | 77.5% | |
Unknown | 93.2% | 93.7% | 93.6% | |
First dialysis modality | Home hemodialysis | 100.0% | 99.8% | 99.9% |
In-center hemodialysis | 97.8% | 98.6% | 99.9% | |
Peritoneal dialysis | 97.4% | 98.7% | 99.8% | |
First vascular access used at dialysis start | AV graft | 99.9% | 100.0% | 100.0% |
Fistula | 98.9% | 99.1% | 99.4% | |
Catheter | 93.5% | 96.2% | 99.4% | |
PD catheter | 98.8% | 99.0% | 100.0% | |
Unknown | 92.4% | 93.8% | 94.3% | |
Most recent vascular access before the index date | AV graft | 98.7% | 99.8% | 98.9% |
Fistula | 91.9% | 94.8% | 97.7% | |
Catheter | 89.9% | 94.0% | 97.4% | |
Patients 65+ years in ODB in the 6 months prior to index date | Yes | 97.5% | 99.3% | 99.4% |
Unique hypertensive drugs 6 months before the index date | Mean ± standard deviation | 97.1% | 99.9% | 99.5% |
Prescribed hypertensive drugs | Angiotensin-converting enzyme (ACE) inhibitors | 99.4% | 99.3% | 99.5% |
Angiotensin II receptor blocker | 90.7% | 96.1% | 96.9% | |
Beta-blockers | 99.7% | 100.0% | 99.9% | |
Calcium channel blocker | 98.1% | 100.0% | 99.6% | |
Diuretics | 91.9% | 97.0% | 95.6% | |
CABG/PCI | Yes | 99.4% | 99.5% | 100.0% |
Heart failure | Yes | 96.8% | 100.0% | 99.8% |
Diabetes mellitus | Yes | 99.0% | 100.0% | 100.0% |
Ischemic stroke | Yes | 100.0% | 100.0% | 100.0% |
Lower extremity amputation | Yes | 99.9% | 100.0% | 100.0% |
Lung disease (COPD) | Yes | 99.0% | 99.6% | 100.0% |
Myocardial infarction | Yes | 99.2% | 100.0% | 100.0% |
Major cancer | Yes | 100.0% | 100.0% | 100.0% |
Peripheral vascular disease | Yes | 90.7% | 97.2% | 91.4% |
Modified Charlson comorbidity Score | Mean ± standard deviation | 96.8% | 99.9% | 100.0% |
2 | 97.7% | 100.0% | 100.0% | |
3 | 100.0% | 100.0% | 100.0% | |
4 | 100.0% | 100.0% | 100.0% | |
5+ | 98.9% | 100.0% | 100.0% | |
Having a kidney transplant before the index date | Yes | 100.0% | 100.0% | 100.0% |
Number of hospital admissions in the year before the index date | Mean ± standard deviation | 93.9% | 98.4% | 98.4% |
0 | 78.4% | 76.4% | 81.1% | |
1 to 3 | 99.5% | 99.6% | 99.9% | |
4 to 6 | 99.4% | 99.6% | 99.5% | |
7 to 9 | 100.0% | 99.9% | 100.0% | |
10+ | 92.1% | 92.0% | 94.6% | |
Long term care facility utilization in the year before the index date | Yes | 81.3% | 86.6% | 86.1% |
Time since the first date on dialysis (days) | Mean ± standard deviation | 88.1% | 94.0% | 94.4% |