Table 1 Time windows for data extraction. All data points within the time window will be extracted
Variables | Attribute | Type of variable | ITT cohort | Alert cohort |
|---|---|---|---|---|
Age (years) | ||||
Sex | ||||
Location before ward check-in | All values | |||
Service | All values | |||
Admission diagnoses, main and secondary | All ICD-10-AMa | |||
Problem list | All ICD-10-AMa | |||
Discharge diagnosis | All ICD-10-AMa | |||
Alert criteria | Baseline data | |||
Alert count | All alert dates and times | Baseline data | ||
Time to acknowledgment by nurse and physician | First alert: time to acknowledgment by nurse and by physician | Process measure | ||
Vital signs (heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory rate (RR), temperature) | All values, dates and times | Baseline data | Check-in to + 12 h | − 12 h to alert time |
The same vital signs except for temperature | All values, dates and times | Physiologic outcome | Alert time to + 12 h | |
Lactate | All values, dates and times | Baseline data | − 12 to + 12 h | − 12 h to alert time |
Lactate | All values, dates and times | Process measure, physiologic outcome | Alert time to + 12 h | |
Other blood tests results (white blood cell count, bilirubin, creatinine) | All values, dates and times | Baseline data | − 12 to + 12 h | − 12 h to alert time |
Cultures obtained (blood, respiratory, urine, body fluid ((pleural, ascitic, CSF, joint)) | Yes vs. no, dates and times, results | Baseline data | − 12 to + 12 h | − 12 h to alert time |
Cultures obtained (blood, respiratory, urine, body fluid ((pleural, ascitic, CSF, joint)) | Yes vs. no, dates and times, results | Process measure | Alert time to + 12 h | |
Intravenous fluids administration prescribed | Yes vs. no, date and time | Baseline data | − 12 to + 12 h | − 12 h to alert time |
Yes vs. no, date and times | Process measure | Alert to + 12 h | ||
Hemodialysis | Yes vs. no | Baseline data | Dialysis (hemodialysis) before check-in as outpatient or as in patient in the week preceding check-in | Dialysis (hemodialysis) before alert as outpatient or as in patient in the week preceding check-in |
Yes vs. no, first date and time only | Outcome | Hemodialysis post check-in during this hospital stay (including during ICU stay) | Dialysis within 14 days from the alert (including during ICU stay) | |
Continuous renal replacement therapy (CRRT) | Yes vs. no, first date and time only | Outcome | CRRT post-check-in during this hospital stay (including during ICU stay) | CRRT within 14 days from the alert (including during ICU stay) |
Vasopressors (norepinephrine, dopamine, epinephrine, dobutamine, phenylephrine, vasopressin) | Yes vs. no, date and time of initiation | Outcome | Check-in to 90 days | Alert to 14 days |
Mechanical ventilation (except operation room) | Yes vs. no, date and time of initiation | Outcome | Check-in to 90 days | Alert to 14 days |
ICU admission | Yes vs. no, date and time of initiation, number of days in ICU | Outcome | Check-in to 90 days | Alert to 14 days |
Critical care rapid response team (CCRT) activation | Yes vs. no, date and time | Outcome | Check-in to 90 days | Alert to 14 days |
Code blue | Yes vs. no, date and time | Outcome | Check-in to 90 days | Alert to 14 days |
Hospital discharge | Date and time, status | Outcome | ||
Antibiotics | Yes vs. No, date and timeb | Baseline data | − 12 to + 12 h | − 12 h to alert time |
Process measure | Alert to + 12 h | |||
Yes vs. no, number of days on antibiotics | Outcome | Check-in to 90 days | Alert to 14 days | |
Multidrug-resistant organism (MDROs) | Yes vs. no, type, date and time | Outcome | Check-in to 90 days | Alert to 90 days |
Clostridium difficile (C-diff) | Yes vs. no, date and time | Outcome | Check-in to 90 days | Alert to 90 days |