Treatment sequence | Number of subjects | Details |
---|---|---|
IP4-CHRONOS-A | ||
Control arm | Feasibility, N=30 | Radical radiotherapy or radical prostatectomy (as per physician and patient decision/preference) |
Intervention arm | Feasibility, N=30 | Focal therapy using HIFU or cryotherapy (as per physician and patient decision/preference) |
Total number | Feasibility, N=60 | |
IP4-CHRONOS-B | ||
Control arm | Feasibility, N=20 | Focal therapy using HIFU or cryotherapy (as per physician and patient decision/preference) |
Intervention arm 1 | Feasibility, N=20 | Neoadjuvant finasteride 5mg once daily for a minimum of 12 weeks followed by focal therapy (as per standard care control arm for IP4-CHRONOS-B). |
Intervention arm 2 | Feasibility, N=20 | Bicalutamide 50mg once daily for 12 weeks followed by focal therapy (as per standard care control arm for IP4-CHRONOS-B) |
Total number | Feasibility, N=60 |