Druga | Weight band (kg) |
|---|
30–35 | >35–45 | >45–55 | >55–70 | >70 |
|---|
Bedaquiline | 400 mg QD x 2 weeksb followed by 200 mg 3x/week |
Delamanid | 100 mg BID |
Moxifloxacin | 400 mg |
Levofloxacin | 750 mg | 1000 mg |
Linezolidc | 600 mg QD up to week 16 (followed by 300 mg QD or 600 mg 3×/week) |
Clofazimine | 100 mg |
Pyrazinamide | 800 mg | 1200 mg | 1600 mg | 2000 mg |
- aDosing is once a day unless otherwise indicated
- bThe loading dose of bedaquiline treatment comprises 2 weeks of 400 mg QD. If the patient is already receiving bedaquiline treatment, bedaquiline within the experimental regimen should be dosed as a continuation of that treatment (i.e. only remaining doses of the 2-week loading dose should be administered and a load should not be restarted if it was already completed at time of study treatment initiation)
- cLinezolid dosing is routinely modified at week 16 or sooner if necessary to reduce toxicity related to linezolid. The modification entails either decreased (300 mg daily) or intermittent (600 mg 3×/week) dosing as defined by balanced randomization
