Table 2 Example template of recommended content for the schedule of enrolment, interventions, and assessments*

Enrollment

 Eligibility screen

X

 Informed consent

X

 Allocation

X

Study arms

 Intervention group

X

X

X

X

X

 Active control group

X

X

X

Assessments

 Sociodemographic characteristics

X

 Weight/height/BMI

X

X

X

 Health parameters (medication, diseases)

X

X

X

 Cognitive function (MoCA, TMT A&B)

X

X

X

 Performance in the cycle course

X

X

X

 Physical performance (SPPB)

X

X

X

 Quality of life (EuroQoL-5D + VAS)

X

X

X

 Falls/fear of falling (FES-I short form)

X

X

X

 Bicycle-related Parameters (cycled distance, self-reported cycling behavior)

X

X

X

Biological specimen

 Saliva samples

X

3x¹

3x¹

X

X

 CRP (capillary blood sample)

X

X

X

 Hair sample

X

X

X