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Table 3 Inclusion criteria of NERD

From: Efficacy and safety of the Chinese herbal formula Hewei Jiangni recipe for NERD with cold-heat complex syndrome: study protocol for a double-blinded randomized controlled trial

Those who have the typical clinical symptoms of NERD, such as heartburn and reflux, persist or recur for more than 3 months, and the above symptoms have a negative impact on the quality of life of the patients.
Those who have atypical or extraesophageal symptoms, such as epigastric pain, abdominal distension, belching, non-cardiogenic chest pain, pharyngitis, cough, asthma, or foreign body sensation in the throat, which persist or recur for more than 3 months, the above symptoms have a negative impact on the patient’s quality of life: mild symptoms ≥ 2 days in a week, or moderate and severe symptoms ≥ 1 days in a week.
Reflux diagnostic questionnaire (RDQ) scale symptom score ≥ 12, which is for diagnosis of reflux diseases in the China gastroesophageal reflux Research Cooperation Group.
Those who have no esophageal mucosal lesions and Barrett esophageal manifestations by gastroscopy.
Tweny-four-hour esophageal impedance-PH monitoring: impedance records showed reflux events. At the same time, symptom association probability (SAP) is used to determine the relationship between symptoms and reflux. If SAP > 95%, symptoms will be considered related to reflux.
  1. Diagnostic criteria: 1&3&4 or 2&4&5