• Clinical observations: pulse, blood pressure, respiratory rate and temperature • Blood tests:  ◦ Haematology: full blood count, screen for sickle cell trait and thalassemia  ◦ Biochemistry: sodium, potassium, urea, creatinine, albumin, alanine aminotransferase (ALT) and bilirubin  ◦ Diagnostic serology: HIV antibodies  ◦ Immunological assays of prior exposure to malaria/assessment of immunity to malaria  ◦ Diagnostic malaria tests (PCR and microscopy) • Urinalysis: for protein, glucose or blood cells • Urinary beta-Human Chorionic Gonadotrophin (β-hCG) for all females • Electrocardiogram (ECG) |