Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial

Table 3 Outcomes

Primary endpoint ► Alteration of transcriptomic profile of human tongue tissue as changes in expression level from baseline to follow-up after 16 weeks of treatment, measured by RNA sequencing ►Change in taste sensitivity as detected by chemical gustometry
Secondary endpoints ► Change in neural response to visual food cues in reward processing regions as assessed by functional MRI ► Change in body weight ► Change in fat mass as determined by DXA ► Change in eating behaviour

Abbreviations: RNA sequencing ribonucleic acid sequencing, DXA dual-energy X-ray absorptiometry, functional MRI functional magnetic resonance imaging

ISSN: 1745-6215