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Table 2 Probability of DLT at each of five dose levels for five different dose-toxicity curves. Plateau calibration configuration curves for target DLT probability θ=0.35 and five test dose levels

From: TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis

Curve

Dose level

1

2

3

4

5

1

0.35

0.52

0.52

0.52

0.52

2

0.21

0.35

0.52

0.52

0.52

3

0.21

0.21

0.35

0.52

0.52

4

0.21

0.21

0.21

0.35

0.52

5

0.21

0.21

0.21

0.21

0.35

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Trials

ISSN: 1745-6215