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Table 1 Study and patient characteristics for the 65 delirium trials

From: Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review

  Overall Prevention Treatment Both
n = 65 n = 44 n = 12 n = 9
Study characteristics
 Sample size, median [Q1,Q3] 113 [70, 198] 109 [70, 158] 104 [72, 238] 141[101, 164]
 Study start year, median [Q1, Q3] 2012 [2009, 2014] 2013 [2009, 2014] 2009 [2005, 2012] 2010 [2009, 2011]
 Fundinga
  Governmental funding 20 (31) 9 (21) 5 (42) 6 (67)
  No external funding 18 (28) 12 (27) 3 (25) 3 (33)
  Industry funding 8 (12) 5 (11) 2 (17) 1 (11)
  Non-profit sources (non-gov’t) 5 (8) 3 (7) 2 (17) 0 (0)
  Other source of funding 7 (11) 6 (14) 0 (0) 1 (11)
  Unclear funding source 16 (25) 13 (30) 3 (25) 0 (0)
 Country/regiona
  USA 16 (25) 10 (23) 4 (33) 2 (22)
  China 12 (19) 10 (23) 1 (8) 1 (11)
  Iran 8 (12) 7 (16) 1 (8) 0 (0)
  Canada 5 (8) 4 (9) 1 (8) 0 (0)
  Europeb 5 (8) 2 (5) 0 (0) 3 (33)
  Japan 2 (3) 2 (5) 0 (0) 0 (0)
  Otherc 21 (32) 12 (27) 5 (42) 3 (33)
 Patient typea,e
  Cardiac surgery 22 (34) 16 (36) 3 (25) 3 (33)
  Surgery 19 (29) 15 (34) 3 (325) 1 (11)
  ARFf 17 (26) 10 (23) 3 (25) 4 (44)
  Medical 6 (9) 2 (5) 3 (25) 1 (11)
  Other 14 (22) 6 (14) 6 (50) 2 (22)
 ICU typea
  General or mixedd 13 (20) 6 (14) 4 (33) 3 (33)
  Surgical 11 (17) 6 (14) 4 (33) 1 (11)
  Cardiovascular surgery 10 (15) 10 (23) 0 (0) 0 (0)
  Medical 9 (14) 4 (9) 4 (33) 1 (11)
  Coronary care 1 (2) 0 (0) 0 (0) 1 (11)
  Unspecified 28 (43) 20 (46) 5 (42) 3 (33)
Patient characteristics
 Average age, median [Q1,Q3] 62 [59, 69] 63 [59, 69] 62 [55, 65] 66 [63, 68]
 Proportion male, median [Q1,Q3] 62 [53, 72] 63 [55, 70] 61 [51374] 58 [50, 60]
 Severity of illness measurea
  APACHE II 23 (35) 13 (29.5) 7 (58) 3 (33)
  APACHE III 2 (3) 1 (2) 0 (0) 1 (11)
  APACHE IV 1 (2) 1 (2) 0 (0) 0 (0)
  SAPS II 1 (2) 1 (2) 0 (0) 0 (0)
  SAPS III 1 (2) 1 (2) 0 (0) 0 (0)
  SOFA 6 (9) 4 (9) 1 (8) 1 (11)
 Average APACHE II, median [Q1,Q3] 15 [11, 20] 15 [11, 18] 13 [11, 20] 20 [18, 21]
 Average SOFA, median [Q1,Q3] 5 [4, 7] 4 [4, 5] 6 [6, 6] 9 [9, 9]
  1. Values in the table are count (%) unless otherwise noted. The RCTs may be counted in several categories for each characteristic, so that the count (%) will not necessarily sum to 65 (100%)
  2. Abbreviation: ARF Acute respiratory failure
  3. aMultiple categories could be selected for each delirium RCT, so that the count (%) will not necessarily sum to 65 (100%)
  4. bEurope includes Switzerland (1 prevention trial), Italy (1 prevention trial, 1 prevention/treatment trial), and Great Britain (2 prevention/treatment trials)
  5. cOther includes Egypt (3), Netherlands (3), Turkey (3), South Korea (2), Thailand (2), Australia (1), Belgium (1), Chile (1), India (1), Saudia Arabia (1), and Serbia (1)
  6. dMixed ICU is a medical-surgical ICU
  7. eCardiac surgery and general surgery are mutually exclusive. If a trial recruited both cardiac and non-cardiac surgery patients, it was classified as general surgery. Surgery includes patients with a “trauma” designation
  8. fAcute respiratory failure includes trials conducted among mechanically ventilated, acute respiratory, or acute respiratory distress syndrome patients