From: Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review
Overall | Prevention | Treatment | Both | |
---|---|---|---|---|
n = 65 | n = 44 | n = 12 | n = 9 | |
Study characteristics | ||||
Sample size, median [Q1,Q3] | 113 [70, 198] | 109 [70, 158] | 104 [72, 238] | 141[101, 164] |
Study start year, median [Q1, Q3] | 2012 [2009, 2014] | 2013 [2009, 2014] | 2009 [2005, 2012] | 2010 [2009, 2011] |
Fundinga | ||||
Governmental funding | 20 (31) | 9 (21) | 5 (42) | 6 (67) |
No external funding | 18 (28) | 12 (27) | 3 (25) | 3 (33) |
Industry funding | 8 (12) | 5 (11) | 2 (17) | 1 (11) |
Non-profit sources (non-gov’t) | 5 (8) | 3 (7) | 2 (17) | 0 (0) |
Other source of funding | 7 (11) | 6 (14) | 0 (0) | 1 (11) |
Unclear funding source | 16 (25) | 13 (30) | 3 (25) | 0 (0) |
Country/regiona | ||||
USA | 16 (25) | 10 (23) | 4 (33) | 2 (22) |
China | 12 (19) | 10 (23) | 1 (8) | 1 (11) |
Iran | 8 (12) | 7 (16) | 1 (8) | 0 (0) |
Canada | 5 (8) | 4 (9) | 1 (8) | 0 (0) |
Europeb | 5 (8) | 2 (5) | 0 (0) | 3 (33) |
Japan | 2 (3) | 2 (5) | 0 (0) | 0 (0) |
Otherc | 21 (32) | 12 (27) | 5 (42) | 3 (33) |
Patient typea,e | ||||
Cardiac surgery | 22 (34) | 16 (36) | 3 (25) | 3 (33) |
Surgery | 19 (29) | 15 (34) | 3 (325) | 1 (11) |
ARFf | 17 (26) | 10 (23) | 3 (25) | 4 (44) |
Medical | 6 (9) | 2 (5) | 3 (25) | 1 (11) |
Other | 14 (22) | 6 (14) | 6 (50) | 2 (22) |
ICU typea | ||||
General or mixedd | 13 (20) | 6 (14) | 4 (33) | 3 (33) |
Surgical | 11 (17) | 6 (14) | 4 (33) | 1 (11) |
Cardiovascular surgery | 10 (15) | 10 (23) | 0 (0) | 0 (0) |
Medical | 9 (14) | 4 (9) | 4 (33) | 1 (11) |
Coronary care | 1 (2) | 0 (0) | 0 (0) | 1 (11) |
Unspecified | 28 (43) | 20 (46) | 5 (42) | 3 (33) |
Patient characteristics | ||||
Average age, median [Q1,Q3] | 62 [59, 69] | 63 [59, 69] | 62 [55, 65] | 66 [63, 68] |
Proportion male, median [Q1,Q3] | 62 [53, 72] | 63 [55, 70] | 61 [51374] | 58 [50, 60] |
Severity of illness measurea | ||||
APACHE II | 23 (35) | 13 (29.5) | 7 (58) | 3 (33) |
APACHE III | 2 (3) | 1 (2) | 0 (0) | 1 (11) |
APACHE IV | 1 (2) | 1 (2) | 0 (0) | 0 (0) |
SAPS II | 1 (2) | 1 (2) | 0 (0) | 0 (0) |
SAPS III | 1 (2) | 1 (2) | 0 (0) | 0 (0) |
SOFA | 6 (9) | 4 (9) | 1 (8) | 1 (11) |
Average APACHE II, median [Q1,Q3] | 15 [11, 20] | 15 [11, 18] | 13 [11, 20] | 20 [18, 21] |
Average SOFA, median [Q1,Q3] | 5 [4, 7] | 4 [4, 5] | 6 [6, 6] | 9 [9, 9] |