Table 1 Primary and secondary endpoints

Primary endpoint

• LDL-C cholesterol

Major secondary endpoint

• Symptom-limited bicycle ergometer test (Watts and estimated VO₂max)

Other secondary endpoints

• Dynamic unilateral heel-lift and unilateral shoulder-flexion tests (n)

• Self-reported activity level (levels 1–6, days/week)

• Fasting lipid levels (TC, HDL-C, TGA, small dense LDL-C, apo A, apo B, Lp(a), oxidized LDL)

• Fasting insulin, c-peptide, creatinine, glucose, cystatin C

• HbA1c, hs-CRP, NT-proBNP, troponin-I, IL-6

• Resting heart rate and blood pressure

• Left ventricular systolic function

• Untargeted plasma metabolome

• Gut microbiota composition