Connecting the Dots: a cluster-randomized clinical trial integrating standardized autism spectrum disorders screening, high-quality treatment, and long-term outcomes

Table 1 Schedule of measures

Screening measures		Well-child check-ups with pediatric providers
Screening measures		<18 months	18 months		24 months	48 months
Experimental	M-CHAT-R/F		X		Optional	X
	Provider concerns	Optional	X		Optional	X
	SCQ					X
Usual care	M-CHAT-R/F					X
	Provider concerns	Optional	Optional		Optional	X
	SCQ					X
Evaluation measures		Diagnostic^a	Post-treat^a		48 months	60 months
Parent measures (completed at home)	CBCL^b	X	X		X	X
	History forms (family, medical, supplemental)^c	X	X		X	X
	PDDBI	X	X		X	X
Evaluation measures	MSEL	X	X		X	X
	VABS-3	X	X		X	X
	DAS-II					X^d
	ADOS-2^e	X			X	X
	DIAL-4					X
	BOSCC	X	X		X	X
	Head circumference	X	X		X	X
	TASI^f	X	X
	ADI-R				X	X
	Eye-tracking	X	X		X	X
	Diagnostic Checklist	X	X		X	X
Treatment measures (at home)		Pre-treat	During treat	Post-treat^a	48 months	60 months
Parent measures	PSI-4	X	X^g		X	X
Parent measures	FES		X^g
Child measures	ESDM Checklist	X	X^h	X
Child measures	CPP	X		X	X	X

M-CHAT-R/F, Modified Checklist for Autism in Toddlers, Revised, with Follow-Up; SCQ, Social Communication Questionnaire; CBCL, Child Behavior Checklist; PDDBI, Pervasive Developmental Disorder Behavior Inventory; MSEL, Mullen Scales of Early Learning; Vineland-3, Vineland Adaptive Behavior Scales, 3rd Edition; DAS-II, Differential Abilities Scale, 2nd Edition; ADOS-2, Autism Diagnostic Observation Schedule, 2nd Edition; DIAL-4, Developmental Indicators for Assessment of Learning, 4th Edition; BOSCC, Brief Observation of Social Communication Change; TASI, Toddler ASD Symptom Inventory; ADI-R, Autism Diagnostic Interview, Revised; PSI-4, Parent Stress Index, 4th Edition; FES, Family Empowerment Scale; ESDM, Early Start Denver Model; CPP, Communication Play Protocol
^aDiagnostic: initial evaluation; post-treatment: evaluation following 12 months of treatment
^b18 months and older
^cA re-evaluation history form may be utilized at later evaluations
^dUse instead of Mullen if skill level at ceiling on Mullen
^eThe appropriate module will be selected based upon the age of the child and verbal ability—toddler module (30 months or less with no phrase speech), module 1 (31 months or more with no phrase speech), and module 2 (phrase speech)
^fTASI omitted if child older than 36 months
^gAdministered at month 9 of treatment
^hAdministered quarterly during treatment

ISSN: 1745-6215