Active elderly and health—can moderate exercise improve health and wellbeing in older adults? Protocol for a randomized controlled trial

Table 1 Schedule of enrolment, interventions, and assessments

	Study period
Time point	tx	t0		12 weeks	t1	t2	t3
	Enrollment	Baseline	Allocation	Treatment	Post-testing	24 week F-U	48 week F-U
Enrollment
Eligibility screen	X
Informed consent	X
Allocation			X
Interventions
Physical activity				←--------→
Recreational activity				←--------→
Adverse events monitoring				←--------→
Assessment
Medical assessment	X				X
Anthropometric measurement	X				X
Demography	X
Questionnaires
SF-12		X			X	X	X
BSRS		X			X	X	X
IPAQ		X				X	X
PHQ-9		X			X	X	X
SIP-RS		X			X	X	X
NPRS		X			X	X	X
Cognitive testing
ACE		X			X	X	X
Physiological testing
STS		X			X
TUG		X			X
Laboratory tests
Glycaemia		X			X
Total and HDL cholesterol		X			X
Triglycerides		X			X
Melatonin		X			X
IGF-1		X			X
ESR		X			X
CRP		X			X
IgG, IgA, IgM		X			X
PHA test		X			X
T-helper Th1, Th2, Th17		X			X

Abbreviations: ACE, Addenbrooke’s Cognitive Examination; BSRS, Brief Social Rhythms Scale; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; Ig, immunoglobulin; HDL, high-density lipoprotein cholesterol; IGF-1, insulin-like growth factor-1; IPAQ, International Physical Activity Questionnaire; NNT, number needed to treat; NPRS, Numeric Pain Rating Scale; PHA, phytohemagglutinin; PHQ-9, Patient Health Questionnaire-9 items; SF-12, Short Form Health Survey 12 items; SIP-RS, Sickness Impact Profile-Roland Scale; STS, sit-to-stand; T, thymus; TUG, Timed-Up-and-Go. All items can be found in the protocol

ISSN: 1745-6215