Table 2 Funding opportunities for independent clinical repurposing research
From: Exploring new uses for existing drugs: innovative mechanisms to fund independent clinical research
| Funding source | Organisation | Name of funding opportunitya | Available funds | Duration of research | Geographic area | Disease area |
|---|---|---|---|---|---|---|
| Government organisations | Belgian healthcare knowledge center (KCE) (BE) | KCE investigator-led trials | €10,000,000 per year, no defined max. amount per project | Results preferably within 5 years | International study possible under certain conditions | All |
| ZonMw (NL) | Goed Gebruik Geneesmiddelen – Drug Rediscovery | Max. €1,000,000 per call | Not specified | International study possible if chief investigator and lead institution are NL-based | All | |
| National Institute for Health Research (NIHR) and Medical Research Council (MRC) (UK) | 19/136 call for evaluating interventions for the diagnosis and treatment of autoimmune diseases | Case by case negotiations | Not specified | International study possible if chief investigator and lead institution are UK-based | Autoimmune diseases | |
| Companies | Bayer | Grants4Indications | Case by case negotiations | Max. 2 years | International | All |
| Not-for-profit organisations | CuresWithinReach | ReGRoW Pilot | US$ 25,000–50,000 per project | 12–36 months | Low and lower-middle-income-countries (LMICs) | Any unsolved disease in LMICs |
| Michael J. Fox Foundation | Therapeutic Pipeline Program | US$2,000,000 per project | 2–3 years | International | Parkinson’s disease | |
| The Anticancer Fund (ACF) and Rising Tide Foundation for Clinical Cancer Research (RTFCCR) | The RTFCCR/ACF Multi-arm Clinical Trial Award | US$ 3,000,000 in total | Not specified | International | Cancer |