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Table 5 Detailed timetable of procedures and assessments in periods 1, 2, 3, and 4

From: IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)

  1. * The PK sample on next day can be taken at any suitable time provided that the exact time of sampling is precisely recorded. ** Hyperalgesia testing at the sensitized and contralateral forearm, harmonized across all four IMI2-PainCare-BioPain RCTs