Fig. 5From: IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)Statistical procedure. The sequentially rejective multiple testing approach used for the selected confirmatory analyses. The two primary endpoints (LEP N2-P2 and PEP-N2-P2) will be tested in parallel, splitting the overall α equally between the endpoint tests. If any of these two tests shows significant differences, key secondary tests will be conducted using the α-levels as passed on from initial/prior tests according to specified weightsBack to article page