Table 2 Full exclusion criteria
Exclusion criteria | |
|---|---|
Consent/communication | Inability to speak or read English |
Physiological health | |
Diagnosis | Unstable medical or neurologic condition as assessed by the study physician |
Lab work | Significant renal or hepatic impairment |
Vital signs | Cardiovascular conditions including abnormal heart rate seen by ECG Resting blood pressure not exceeding 160 mmHg systolic and 90 mmHg diastolic Body weight between 50 and 120 kg |
Medical history | Contraindications for MRI scanning |
Mental health | |
Diagnosis | Lifetime history of major depressive disorder, schizophrenia or other psychotic disorders, or bipolar I or II disorder as assessed by the Mini International Neuropsychiatric Interview (MINI) Current diagnosis of PTSD, anxiety and panic disorders, OCD, dysthymic disorder, anorexia, and bulimia as assessed by the Standard MINI |
Current risk | Elevated of suicide as determined by study psychiatrist using the Columbia-Suicide Severity Rating Scale (C-SSRS) Elevated risk of developing psychosis as determined by the study psychiatrist using the Comprehensive Assessment of At Risk Mental States (CAARMS) |
Family diagnosis | First-degree relatives diagnosed with schizophrenia or other primary psychotic disorder, or bipolar I or II disorder |
Medication | Current use of any prescribed psychotropic medication |
Substance use | Substance use disorder in the previous 3 months as assessed with a New Zealand modified version of the NM-ASSIST Failed breathalyser and/or multipanel drug urine tests at screening with one follow up in trial Use of serotonergic psychedelic drugs in the last year Lifetime history of psychedelic microdosing |