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Table 2 Change in VACS index (95% confidence interval) between baseline and 18 months by randomization group and cumulative adherence (high versus low). Estimated using inverse probability weighting. ZINC trial 2013–2015

From: Per-protocol analysis of the ZINC trial for HIV disease among alcohol users

Randomization group

High adherencea

Low adherenceb

Difference (high versus low adherence)

Zinc

−2.16 (−8.07, 3.59)

5.23 (−2.19, 10.78)

− 7.39 (−17.13, 2.42)

Placebo

5.84 (0.73, 11.80)

2.70 (−5.80, 15.06)

3.14 (− 9.90, 13.84)

  1. aHigh adherence: cumulative adherence ≥80% based on self-reported pill count
  2. bLow adherence: cumulative adherence < 80% based on self-reported pill count