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Fig. 2 | Trials

Fig. 2

From: A novel preference-informed complementary trial (PICT) design for clinical trial research influenced by strong patient preferences

Fig. 2

Schema of the No OUCH trials using a pooled analysis. Participants would be asked to choose between two trials with the opioid-inclusive trial containing all three treatment options (ibuprofen; ibuprofen + acetaminophen; ibuprofen + hydromorphone) and non-opioid trial containing non-opioid options (ibuprofen; ibuprofen + acetaminophen) and omitting the opioid option with strong preferences that may deter participation (ibuprofen + hydromorphone). Participants would then be randomized to the available treatment options according to their choice of trial. If there is no clinical or statistical evidence that trial populations have important differences, then data from all arms can be pooled for a single analysis

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Trials

ISSN: 1745-6215