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Fig. 1 | Trials

Fig. 1

From: A novel preference-informed complementary trial (PICT) design for clinical trial research influenced by strong patient preferences

Fig. 1

Schema of the PICT design using a pooled analysis. Participants would be asked to choose between two trials with Trial 2 containing all three treatment options (A, B, C) and Trial 1 containing two treatment options (A, B) and omitting the option with strong preferences that may deter participation (C). Participants would then be randomized to the available treatment options according to their choice of trial. If there is no clinical or statistical evidence that trial populations have important differences, then data from all arms can be pooled for a single analysis

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