Table 2 Summary of primary and secondary outcome domains and data items across all 72 included studies, classified according to core areas and categories defined by Dodd et al. [90]. Percentage values less than 1% are not reported
Taxonomy core area | Taxonomy categories | Number of data items (primary outcome domains) | % of total number of primary outcome domains | Number of data items (secondary outcome domains) | % of total number of secondary outcome domains | Number of unique outcome domains reported as primary | Number of unique outcome domains reported as secondary only |
|---|---|---|---|---|---|---|---|
Death | 1: Mortality / survival | 0 | – | 0 | – | 0 | 0 |
Physiological or clinical | 6: Ear and labyrinth outcomes | 194 | 55.4% | 90 | 52.9% | 15 | 3 |
7: Eye outcomes | 0 | – | 1 | – | 1 | 0 | |
9: General outcomes | 9 | 2.6% | 1 | – | 2 | 0 | |
17: Nervous system outcomes | 3 | – | 3 | 1.8% | 2 | 0 | |
21: Psychiatric outcomes | 3 | – | 0 | – | 1 | 0 | |
23: Skin and subcutaneous tissue outcomes | 2 | – | 0 | – | 1 | 0 | |
Life impact | 25: Physical functioning | 2 | – | 5 | 3.3% | 2 | 3 |
26: Social functioning | 1 | – | 3 | 2.9% | 1 | 2 | |
27: Role functioning | 1 | – | 1 | – | 1 | 0 | |
28: Emotional functioning / well-being | 7 | 2.0% | 5 | 3.3% | 5 | 3 | |
29: Cognitive functioning | 2 | – | 3 | 2.9% | 1 | 2 | |
30: Global quality of life | 55 | 15.7% | 16 | 9.4% | 7 | 0 | |
31: Perceived health status | 1 | – | – | – | 1 | 0 | |
32a: Delivery of care—satisfaction / patient preference | 51 | 14.6% | 17 | 10.0% | 10 | 2 | |
32b: Delivery of care—acceptability and availability | 0 | – | 1 | – | 0 | 1 | |
Resource use | 34: Economic | 2 | – | 2 | 1.2% | 2 | 0 |
35: Hospital | 1 | – | 0 | – | 1 | 0 | |
37: Societal / carer burden | 0 | – | 1 | – | 0 | 1 | |
Adverse events | 38: Adverse events / effects | 11 | 3.1% | 5 | 2.9% | 3 | 0 |
Cannot code | 0: Cannot code | 5 | 1.4% | 17 | 10.0% | N/A | N/A |
Total | 350 | 170 | 55 | 18 |