Table 2 Ephedrine study interventions and assessments
Study period | ||
|---|---|---|
Enrolment | Allocation | |
Timepoint | Pre-anesthesia visit | General anesthesia |
Enrolment: | ||
Eligibility screen | X | |
Informed consent | X | X (check) |
General anesthesia | X | X |
Randomization eligibility: decrease in mean blood pressure | X | |
Randomization | X | |
Interventions: | ||
Ephedrine 0.6, 0.8, 1.0, 1.2, 1.4%, tested doses | X | |
Ephedrine 0.1%, control group | X | |
Assessments: | ||
Systolic and diastolic blood pressure (baseline and every minute) | X | |
Mean blood pressure (baseline and every minute) | X | |
Heart rate, ScO2, PaCO2 every 10 min post ephedrine | X | |
Adverse events and concomitant medications | X | |