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Table 2 Ephedrine study interventions and assessments

From: Determination of the optimal dose of ephedrine in the treatment of arterial hypotension due to general anesthesia in neonates and infants below 6 months old: the ephedrine study protocol for a randomized, open-label, controlled, dose escalation trial

  Study period
  Enrolment Allocation
Timepoint Pre-anesthesia visit General anesthesia
Enrolment:
Eligibility screen X  
Informed consent X X (check)
General anesthesia X X
Randomization eligibility: decrease in mean blood pressure   X
Randomization   X
Interventions:
Ephedrine 0.6, 0.8, 1.0, 1.2, 1.4%, tested doses   X
Ephedrine 0.1%, control group   X
Assessments:
Systolic and diastolic blood pressure (baseline and every minute)   X
Mean blood pressure (baseline and every minute)   X
Heart rate, ScO2, PaCO2 every 10 min post ephedrine   X
Adverse events and concomitant medications   X