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Table 4 Factors related to incomplete clinical trials (N = 138)

From: Study factors associated with the incompletion of clinical trials that include pediatric patients: a retrospective analysis of the European Clinical Trials Database and a lesson from the European region

Variable   Adjusted OR 95% CI
Trial part of an agreed PIP Yes 1.8 [0.7, 4.3]
Both 1.0 [0.1, 8.3]
No 1.0 Reference
Rare disease Yes 1.2 [0.5, 2.7]
No 1.0 Reference
Clinical trials that included newborns or infants and toddlers Yes 1.3 [0.5, 3.4]
No 1.0 Reference
Number of countries in which the trial was conducted Increment of one country 1.3 [1.1, 1.5]
  1. Coefficient of determination; 0.09, Model goodness-of-fit; p = 0.007
  2. Note: PIP pediatric investigation plan, CI confidence interval, OR odds ratio