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Table 4 Comparison of changes in outcome measurements between patients who received Dangguixu-san and those who received placebo for acute lateral ankle sprain (n = 23 each)

From: Effects of Dangguixu-san in patients with acute lateral ankle sprain: a randomized controlled trial

Dependent variables Group (n) Difference (w1–w0) Z (p)a Difference (w5–w0) Z (p)a Difference (w5–w1) Z (p)a
VAS of pain DS (n = 23) 19.91 ± 21.62 − 0.82 (0.412) 32.13 ± 23.65 − 0.63 (0.527) 12.22 ± 22.08 − 2.59 (0.010)
Placebo (n = 23) 24.78 ± 12.83 29.17 ± 16.26 4.39 ± 10.71
Degree of edema DS (n = 23) 0.44 ± 0.93 − 0.66 (0.512) 0.45 ± 0.83 − 0.09 (0.929) 0.01 ± 0.59 − 0.96 (0.338)
Placebo (n = 23) 0.24 ± 0.53 0.40 ± 0.70 0.15 ± 0.61
Total EQ-5D-5L DS (n = 23) 2.13 ± 2.69 − 0.51 (0.609) 3.78 ± 4.22 − 0.48 (0.633) 1.65 ± 4.13 − 1.29 (0.198)
Placebo (n = 23) 2.57 ± 1.78 3.52 ± 2.84 0.96 ± 2.14
Total FAOS DS (n = 23) 61.13 ± 72.52 − 0.91 (0.362) 122.66 ± 107.34 − 0.41 (0.684) 61.53 ± 99.49 − 1.15 (0.249)
Placebo (n = 23) 83.91 ± 74.37 128.46 ± 85.78 44.55 ± 53.31
FAOS Symptom/Rigidity DS (n = 23) 8.36 ± 15.97 − 1.42 (0.155) 20.16 ± 21.87 − 0.08 (0.939) 11.80 ± 17.34 − 2.54 (0.011)
Placebo (n = 23) 14.69 ± 12.83 18.74 ± 17.07 4.05 ± 10.47
FAOS ache DS (n = 23) 15.52 ± 14.41 − 0.80 (0.426) 29.29 ± 22.83 − 1.01 (0.312) 14.25 ± 20.91 − 2.69 (0.007)
Placebo (n = 23) 18.60 ± 16.60 24.41 ± 18.33 5.81 ± 10.12
  1. aMann-Whitney U test