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Table 4 Comparison of changes in outcome measurements between patients who received Dangguixu-san and those who received placebo for acute lateral ankle sprain (n = 23 each)

From: Effects of Dangguixu-san in patients with acute lateral ankle sprain: a randomized controlled trial

Dependent variables

Group (n)

Difference (w1–w0)

Z (p)a

Difference (w5–w0)

Z (p)a

Difference (w5–w1)

Z (p)a

VAS of pain

DS (n = 23)

19.91 ± 21.62

− 0.82 (0.412)

32.13 ± 23.65

− 0.63 (0.527)

12.22 ± 22.08

− 2.59 (0.010)

Placebo (n = 23)

24.78 ± 12.83

29.17 ± 16.26

4.39 ± 10.71

Degree of edema

DS (n = 23)

0.44 ± 0.93

− 0.66 (0.512)

0.45 ± 0.83

− 0.09 (0.929)

0.01 ± 0.59

− 0.96 (0.338)

Placebo (n = 23)

0.24 ± 0.53

0.40 ± 0.70

0.15 ± 0.61

Total EQ-5D-5L

DS (n = 23)

2.13 ± 2.69

− 0.51 (0.609)

3.78 ± 4.22

− 0.48 (0.633)

1.65 ± 4.13

− 1.29 (0.198)

Placebo (n = 23)

2.57 ± 1.78

3.52 ± 2.84

0.96 ± 2.14

Total FAOS

DS (n = 23)

61.13 ± 72.52

− 0.91 (0.362)

122.66 ± 107.34

− 0.41 (0.684)

61.53 ± 99.49

− 1.15 (0.249)

Placebo (n = 23)

83.91 ± 74.37

128.46 ± 85.78

44.55 ± 53.31

FAOS Symptom/Rigidity

DS (n = 23)

8.36 ± 15.97

− 1.42 (0.155)

20.16 ± 21.87

− 0.08 (0.939)

11.80 ± 17.34

− 2.54 (0.011)

Placebo (n = 23)

14.69 ± 12.83

18.74 ± 17.07

4.05 ± 10.47

FAOS ache

DS (n = 23)

15.52 ± 14.41

− 0.80 (0.426)

29.29 ± 22.83

− 1.01 (0.312)

14.25 ± 20.91

− 2.69 (0.007)

Placebo (n = 23)

18.60 ± 16.60

24.41 ± 18.33

5.81 ± 10.12

  1. aMann-Whitney U test