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Table 1 Summary of the characteristics of the randomized controlled trials included in the meta-analysis

From: Dropouts in randomized clinical trials of Korean medicine interventions: a systematic review and meta-analysis

Author (year) Protocol Institutions, n Blinding Sample size (T/C) Study design Treatment intervention Control intervention Disease Severity Treatment period Treatments, n Funding
Choi (2010) [12] Multicenter 4 Single 175 (116/59) Parallel group Acupuncture Usual care Perimenopause and post-menopause NR 4 weeks 12 Yes
Choi (2012) [13] Multicenter 3 Open 150 (75/75) Parallel group Acupuncture Usual care Dry eye Other 8 weeks 12 Yes
Choi (2012) a [14] Single-center 1 Single 42 (14/28) Parallel group Acupuncture Distant and combination point Temporomandibular joint disorder Other 2 weeks 6 Yes
Choi (2015) [15] Single-center 1 Single 30 (15/15) Parallel group Acupuncture No treatment Hypertension Other 8 weeks 16 Yes
Choi (2015) a [16] Multicenter 4 Open 150 (49/51) Parallel group Acupuncture Sham acupuncture Fatigue Chronic 4 weeks 10 Yes
Choi (2018) [17] Single-center 1 Single 30 (15/15) Parallel group Acupuncture Sham acupuncture Functional constipation Other 4 weeks 12 Yes
Choi (2018) a [18] Multicenter 4 Single 126 (63/63) Parallel group Acupuncture Placebo Diabetic peripheral neuropathy Other 8 weeks 16 Yes
Han (2018) [19] Single-center 1 Single 40 (20/20) Parallel group Embedding acupuncture Acupuncture Low back pain Chronic 8 weeks T4/C16 Yes
Jung (2009) [20] Single-center 1 Double 52 (27/25) Parallel group Acupuncture Sham acupuncture Stroke Other 3 days 1 Yes
Kim (2010) [21] Single-center 1 Double 60 (30/30) Parallel group Pharmaco-acupuncture Sham acupuncture Osteoarthritis Other 6 weeks 12 Yes
Kim (2018) b [22] Multicenter 2 Open 16 (9/7) Parallel group Acupuncture No treatment Liver cirrhosis Other 4 weeks 12 Yes
Lee (2011) [23] Single-center 1 Single 54 (57/57) Parallel group Acupuncture Sham acupuncture Perimenopause and post-menopause Other 7 weeks 11 Yes
Lee (2013) [24] Single-center 1 Single 45 (15/30) Parallel group Acupuncture Usual care Neck pain Chronic 3 weeks 9 Yes
Lee (2018) [25] Single-center 1 Double 30 (15/15) Parallel group Acupuncture Sham acupuncture Cancer pain Other 3 weeks NR Yes
Nam (2017) [26] Single-center 1 Open 45 (13/29) Parallel group Acupuncture Electro-acupuncture Tinnitus Other 4 weeks 8 No
Park (2014) [27] Single-center 1 Single 61 (31/30) Parallel group Electro-acupuncture Electro-acupuncture Pain Other NR 1 Yes
Park (2016) [28] Multicenter 2 Open 76 (37/39) Other Acupuncture Acupuncture Functional dyspepsia Other 4 weeks 2 Yes
Shin (2018) [29] Single-center 1 Single 39 (18/21) Parallel group Electro-acupuncture Usual care Low back pain Chronic 4 weeks 8 Yes
Song (2013) [30] Multicenter 3 Double 130 (65/65) Parallel group Acupuncture Sham acupuncture Low back pain Chronic 6 weeks 12 Yes
Yang (2016) [31] Single-center 1 Open 50 (26/24) Parallel group Acupuncture Usual care Lumbar spinal stenosis Other 6 weeks 72–96 Yes
Yoo (2015) [32] Single-center 1 Double 14 (7/7) Parallel group Acupuncture Sham acupuncture Thyroid cancer Other 2 weeks 6 Yes
Chang (2018) [33] Multicenter 2 Double 140 (70/70) Parallel group Herbal medicine Placebo Children with mild short stature Other 24 weeks 336 N.R
Jung (2012) [34] Single-center 1 Double 144 (73/71) Parallel group Herbal medicine Placebo Hwa-byung Other 8 weeks 4 Yes
Kim (2011) [35] Single-center 1 Double 166 (110/56) Parallel group Herbal medicine Other Obesity Other 8 weeks 168 Yes
Kim (2013) [36] Multicenter 2 Double 100 (50/50) Parallel group Herbal medicine Placebo Functional dyspepsia Other 6 weeks 2 Yes
Kim (2014) [37] Single-center 1 Double 50 (25/25) Parallel group Herbal medicine Placebo Obesity Other 8 weeks 2 T/day Yes
Kim (2016) [38] Multicenter 2 Double 96 (48/48) Parallel group Herbal medicine Placebo Oral mucositis Other 8 weeks 2 Yes
Kim (2019) [39] Single-center 1 Double 60 (30/30) Parallel group Herbal medicine Placebo Allergic rhinitis Other 4 weeks 2 Yes
Ko (2017) [40] Single-center 1 Double 32 (16/16) Parallel group Herbal medicine Placebo Cancer-related anorexia Other 4 weeks 2 Yes
Nah (2018) [41] Multicenter 2 Double 143 (70/73) Parallel group Herbal medicine Placebo Knee osteoarthritis Other 6 weeks 1 Yes
Son (2013) [42] Single-center 1 Double 90 (60/30) Parallel group Herbal medicine Placebo Fatigue Chronic 4 weeks 1 Yes
Yoon (2010) [43] Single-center 1 Open 40 (20/20) Parallel group Herbal medicine No treatment Cancer-related fatigue Other 2 weeks 1 Yes
Yoon (2018) [44] Single-center 1 Open 30 (15/15) Parallel group Herbal medicine No treatment Cancer-related sleep disturbance Other 2 weeks 1 Yes
Choi (2011) a [45] Single-center 1 Single 26 (13/13) Parallel group Moxibustion Sham moxibustion Functional constipation Other 4 weeks 12 Yes
Choi (2014) [46] Multicenter 4 Open 212 (102/110) Parallel group Moxibustion Usual care Knee osteoarthritis Other 4 weeks 4 Yes
Yoo (2017) [47] Single-center 1 Single 16 (9/7) Parallel group Moxibustion Sham moxibustion Metastatic cancer Other 2 weeks 10 Yes
Choi (2011) [48] Single-center 1 Open 32 (21/11) Parallel group Cupping No treatment Low back pain Other 2 week 6 Yes
Hong (2012) [49] Single-center 1 Open 40 (20/20) Parallel group Cupping Usual care Neck pain Other 2 weeks 6 Yes
Kim (2015) [50] Single-center 1 Open 27 (15/12) Parallel group Other Usual care Hwa-byung Other 4 weeks 4 Yes
Kim (2016) a [51] Single-center 1 Single 14 (7/7) Parallel group Other Placebo Head and neck cancer Other 8 weeks 4 Yes
Park (2018) [52] Single-center 1 Double 73 (29/29) Parallel group Other Sham Parkinson’s disease Other 12 weeks 24 Yes
Yoon (2016) [53] Single-center 1 Single 30 (15/15) Parallel group Other Usual care Breast cancer Other Other NR Yes
Jung (2014) [54] Multicenter 2 Double 147 (49/49/49) Parallel group Herbal medicine Placebo Anxiety disorder Other 8 weeks 4 Yes
Kim (2018) [55] Multicenter 2 Double 96 (32/32/32) Other Herbal medicine Other Functional dyspepsia Other 8 weeks 1 Yes
Kim (2018) a [56] Multicenter 2 Double 96 (64/32) Parallel group Herbal medicine Placebo Functional dyspepsia Other 8 weeks 2 Yes
Kwon (2019) [57] Single-center 1 Open 24 (12/12) Crossover Herbal medicine Healthy male volunteers Other Other 1 NR
Park (2013) [58] Single-center 1 Double 53 (13/14/14/12) Other Herbal medicine Other Diarrhea-dominant irritable bowel syndrome Other 8 weeks 1 Yes
Kwon (2018) [59] Single-center 1 Open 28 (14/14) Crossover Moxibustion Overactive bladder Other 4 weeks 8–12 NR
Kim (2012) [60] Single-center 1 Open 44 (11/11/11/11) Other Other Other Acne vulgaris Other 4 weeks 8 NR
  1. C control group, NR not reported, T treatment group