Table 1 Inclusion and exclusion criteria

• Angina pectoris

• CAG showed 50 to 70% stenosis in major coronary arteries; FFR > 0.8, IMR > 25;

• Patients received no salvianolate treatment previously.

• Patients with left main disease;

• Patients with severe cardiac insufficiency (New York Heart Association grade III or higher), severe renal insufficiency (eGFR < 60 ml/min), liver dysfunction (ALT > 3 × URL), and asthma history;

• Severe cerebrovascular disease; infection, hematopoietic dysfunction, tumor or mental illness;

• Combined malignant arrhythmia or third degree atrioventricular block;

• Currently taking other Chinese herbs for the treatment of angina;

• Pregnant or breastfeeding women;

• Currently participating in other clinical trials;

• Allergic to known ingredients of salvianolate; and

• The investigator considers it unsuitable for inclusion in other circumstances, or the patient or family members do not agree with the study’s treatment plan.