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Table 1 Inclusion and exclusion criteria

From: MR CLEAN-LATE, a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke in The Netherlands for late arrivals: study protocol for a randomized controlled trial

Inclusion criteria
 1. Clinical diagnosis of acute ischemic stroke
 2. Age ≥ 18
 3. Proximal intracranial anterior circulation occlusion (distal intracranial carotid artery or middle (M1/M2)) cerebral artery confirmed by neuro-imaging (CTA or MRA)
 4. Presence of poor, moderate, or good collateral flow as shown by CTA
 5. Non-contrast CT or MRI ruling out intracranial hemorrhage
 6. Start of EVT (groin puncture) possible between 6 and 24 h after symptom onset or last seen well between 6 and 24 h including wake-up strokes
 7. A score of at least 2 on the NIHSS
 8. Written informed consent (deferred)
Exclusion criteria
 1. Pre-stroke disability which interferes with the assessment of functional outcome at 90 days, i.e., mRS > 2
 2. Cerebral infarction in the previous 6 weeks with residual neurological deficit or signs of large recent infarction on neuroimaging in the territory of the middle cerebral artery
 3. Clinical evidence of hemorrhagic diathesis, confirmed by an INR > 3 and/or a platelet count < 40 × 109/L and/or an APTT > 50 s
 4. Clearly demarcated hypodensity on non-contrast CT in > 1/3 of the middle cerebral artery territory, consistent with current symptoms
 5. Distal intracranial carotid artery occlusion/M1 occlusion, NIHSS ≥ 10, and infarct core ≤ 25 ml and total ischemic volume/infarct core ratio ≥ 2 on CT perfusion or MR diffusion/perfusion
 6. Participation in other trials except for MR ASAP and ARTEMIS
  1. CTA computed tomography angiography, MRA magnetic resonance angiography, NCCT non-contrast computed tomography, MRI magnetic resonance imaging, EVT endovascular treatment, NIH National Institutes of Health, mRS modified Rankin Scale, INR international normalized ratio, APTT activated partial thromboplastin time