Fig. 1

Schedule of enrolment, intervention, and assessments. Arrows represent continuous measurements, and X’s represent an assessment or intervention provided at a specific time point. One asterisk indicates that whenever possible, informed consent will be obtained directly from the patient. If the patient is unable to provide informed consent, we will ask the patients’ relatives and/or an authorized representative for the study consent. Two asterisks indicate that we will ask the patients’ relatives at the earliest possible date, with questions regarding the week prior to arrival at the ICU