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Table 1 Inclusion and exclusion criteria for coArtHA trial

From: The coArtHA trial—identifying the most effective treatment strategies to control arterial hypertension in sub-Saharan Africa: study protocol for a randomized controlled trial

Inclusion criteria

Exclusion criteria

- Adults (≥ 18 years of age)

- African descent and black ethnicity

- Confirmed uncomplicated and currently untreated arterial hypertension* diagnosed at one of the two sites.

- Current hospitalization for any reason

- Refusal to do an HIV-test or indeterminate HIV test result

- History of cardiovascular event in the last month (angina pain, stroke, myocardial infarction or respective diagnosis by a doctor)

- Symptomatic arterial hypertension

 • Blood pressure ≥ 180/110 mmHg plus headache or chest pain) or acute cardiovascular event (see above)

- Acute disease, e.g.

 • Temperature > 37.5 °C or other signs of acute concomitant infection

 • Dyspnea/respiratory distress

 • Acute pain

- Clinical signs of hypertension-mediated organ damage, e.g.

 • Heart failure (bilateral pitting edema, bilateral crackles or pleural effusion, distended jugular veins)

 • Ischemic heart disease (anginal pain on exertion)

 • signs of current ischemic/hemorrhagic stroke (hemiparesis, loss of consciousness)

- Pregnancy (test required for females 18–45 years of age)

- Non-consenting or inability to come for follow-up visits

- Creatinine clearance ≤ 30 ml/min by the Chronic Kidney Disease Epidemiology Formula (CKD-EPI) estimation and measurement with a point-of care creatinine from capillary blood