From: A phase 2 randomised controlled trial of serelaxin to lower portal pressure in cirrhosis (STOPP)
Change from baseline to 1 h | Change from baseline to 2 h | ||||||
---|---|---|---|---|---|---|---|
HVPG (mmHg) | HVPG (mmHg) | HBF (ml/min) | IVCP (mmHg) | Cardiac index (L/min/m2) | SVRI (dyne·s·cm5·m2) | APWV (m/s) | |
Mean ± SD pre serelaxin | 15.9 ± 3.3 | 15.9 ± 3.3 | 1.5 ± 0.8 | 8.2 ± 3.4 | 3.8 ± 0.5 | 1716 ± 398 | 8.1 ± 1.4 |
Mean ± SD post serelaxin | 15.9 ± 2.1 | 15.6 ± 4.3 | 1.2 ± 0.8 | 9.0 ± 2.4 | 4.1 ± 0.8 | 1605 ± 474 | 8.0 ± 2.1 |
Arithmetic mean of difference ± SD (95% CI) | −0.4 ± 1.9 (−3.4, 2.6), p = 0.69 | 0.4 ± 3.5 (−2.3, 3.1), p = 0.76 | −0.3 ± 0.3 (− 0.7, 0.1), p = 0.15 | 0.4 ± 1.7 (1.7, −1.2), p = 0.58 | −0.3 ± 0.7 (− 0.8, 0.3), p = 0.28 | 111 ± 394 (− 192, 414), p = 0.42 | 0.2 ± 0.7 (− 0.4, 0.8), p = 0.49 |
Geometric mean of difference + CV (95% CI) | 1.0 + 0.1 (0.8, 1.2), p = 0.63 | 1.0 + 0.2 (0.9, 1.2), p = 0.68 | 0.8 + 0.2 (0.6, 1.1), p = 0.15 | 1.0 + 0.1 (1.0, 1.1), p = 0.27 | 1.0 + 0.1 (0.9, 1.1), p = 0.44 | 1.0 + 0.0 (1.0, 1.0), p = 0.32 | 1.0 + 0.0 (1.0, 1.1), p = 0.19 |