Table 1 Inclusion and exclusion criteria

 1

Patients with familial cerebral cavernous malformations (FCCM)

 2

History of clinical symptoms or events: ICH, seizures, stroke, permanent or transient focal deficits, intellectual disability, or any other neurological symptoms supposedly related to CCM

 3

Age ≥18 years

 4

Written informed consent to participate in the study prior to any study procedures

 1

Implanted pacemaker or any other condition preventing the MRI examination

 2

Bradycardia (< 50 bpm), second or third-degree AV block or symptomatic hypotension

 3

Unstable diabetes

 4

Severe asthma

 5

Liver and/or renal failure

 6

Current use of verapamil or diltiazem for risk of excessive bradycardia

 7

Previous brain surgery (within 6 months)

 8

Known hypersensitivity to study drug (propranolol or any of the ingredients)

 9

Pregnant or lactating women, or women at risk of childbearing who are not under protection by an accepted method of contraception

 10

Participation to another clinical trial

 11

Inability to cooperate with the trial procedures