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Table 4 Classifications of adverse event (AE) intensity

From: Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial



Grade 1 (mild)

Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated

Grade 2 (moderate)

Minimal, local, or noninvasive intervention indicated; limiting age-appropriate instrumental ADL

Grade 3 (severe)

Medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL

Grade 4 (life-threatening)

Life-threatening consequences; urgent intervention indicated

Grade 5 (death)

Death related to AE

  1. ADL activities of daily living, AE adverse event