Skip to main content

Table 4 Classifications of adverse event (AE) intensity

From: Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial

GradeDescription
Grade 1 (mild)Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
Grade 2 (moderate)Minimal, local, or noninvasive intervention indicated; limiting age-appropriate instrumental ADL
Grade 3 (severe)Medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL
Grade 4 (life-threatening)Life-threatening consequences; urgent intervention indicated
Grade 5 (death)Death related to AE
  1. ADL activities of daily living, AE adverse event