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Table 2 Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease (PERION) exclusion criteria

From: Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial

Criteria type Description of exclusion criteria
Liver comorbidity Patients with any other concurrent liver disease, such as hepatitis C, hepatitis B, or autoimmune hepatitis
Patients with drug-induced symptomatic NAFLD
Other comorbidity Patients with concurrent or past history of any serious cardiac, vascular, hematological, respiratory, hepatic, renal, gastrointestinal, or neuropsychiatric disease
Patients with a history of abdominal or gastrointestinal surgery, except appendicitis
Medication Patients with any change to their orally administered medications within 3 months before informed consent
Patients with diabetes mellitus being treated with insulin injections
Other Patients who have participated in any other clinical study and received study treatment within 1 month before the start of this research (counted from the first day of study medication)
Breastfeeding women or women with possible pregnancy
Other patients who are inappropriate as participants in this research in the opinion of the principal investigator, etc.
  1. NAFLD nonalcoholic fatty liver disease, PERION PERIOdontal treatment for NAFLD