Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial

Table 2 Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease (PERION) exclusion criteria

Criteria type	Description of exclusion criteria
Liver comorbidity	Patients with any other concurrent liver disease, such as hepatitis C, hepatitis B, or autoimmune hepatitis
Liver comorbidity	Patients with drug-induced symptomatic NAFLD
Other comorbidity	Patients with concurrent or past history of any serious cardiac, vascular, hematological, respiratory, hepatic, renal, gastrointestinal, or neuropsychiatric disease
Other comorbidity	Patients with a history of abdominal or gastrointestinal surgery, except appendicitis
Medication	Patients with any change to their orally administered medications within 3 months before informed consent
Medication	Patients with diabetes mellitus being treated with insulin injections
Other	Patients who have participated in any other clinical study and received study treatment within 1 month before the start of this research (counted from the first day of study medication)
	Breastfeeding women or women with possible pregnancy
	Other patients who are inappropriate as participants in this research in the opinion of the principal investigator, etc.

NAFLD nonalcoholic fatty liver disease, PERION PERIOdontal treatment for NAFLD

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