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Table 1 Definition of responders (change of oxygenation) to treatment depending on the patient’s condition

From: Prospective evaluation of hydroxychloroquine in pediatric interstitial lung diseases: Study protocol for an investigator-initiated, randomized controlled, parallel-group clinical trial

Patient’s condition

Measured parameters

Definition of significant change or responder to the initiation of hydroxychloroquine (HCQ)

Definition of significant change or responder to the withdrawal of HCQ

Method of aggregation

In room air

SaO2

Respiratory rate

Increase ≥ 5% in O2 Sat,

or

Decrease in resp. rate ≥ 20%

Decrease ≥ 5% in O2 Sat,

or

Increase in resp. rate ≥ 20%

Proportion of responders

Using O2 supplement

SaO2 withdrawal

Respiratory rate

Increase ≥ 5% in O2 Sat

or

Decrease in resp. rate ≥ 20%

or

Support no longer needed

Decrease ≥ 5% in O2 Sat,

or

Increase in resp. rate ≥ 20%

or

Support newly needed

Proportion of responders

Using high-flow nasal cannula

O2 flow, air flow

Decrease ≥ 20%

or

Support no longer needed

Increase ≥ 20%

or

Support newly needed

Proportion of responders

Ventilated

Oxygenation index

Decrease ≥ 20%

or

Support no longer needed

Increase ≥ 20%

or

Support newly needed

Proportion of responders