Patient’s condition | Measured parameters | Definition of significant change or responder to the initiation of hydroxychloroquine (HCQ) | Definition of significant change or responder to the withdrawal of HCQ | Method of aggregation |
---|---|---|---|---|
In room air | SaO2 Respiratory rate | Increase ≥ 5% in O2 Sat, or Decrease in resp. rate ≥ 20% | Decrease ≥ 5% in O2 Sat, or Increase in resp. rate ≥ 20% | Proportion of responders |
Using O2 supplement | SaO2 withdrawal Respiratory rate | Increase ≥ 5% in O2 Sat or Decrease in resp. rate ≥ 20% or Support no longer needed | Decrease ≥ 5% in O2 Sat, or Increase in resp. rate ≥ 20% or Support newly needed | Proportion of responders |
Using high-flow nasal cannula | O2 flow, air flow | Decrease ≥ 20% or Support no longer needed | Increase ≥ 20% or Support newly needed | Proportion of responders |
Ventilated | Oxygenation index | Decrease ≥ 20% or Support no longer needed | Increase ≥ 20% or Support newly needed | Proportion of responders |