Care after pancreatic resection according to an algorithm for early detection and minimally invasive management of pancreatic fistula versus current practice (PORSCH-trial): design and rationale of a nationwide stepped-wedge cluster-randomized trial

Table 3 Required sample size for different numbers of participating centers

Number of centers	Cluster size^a	Required sample size	Expected inclusions	Inclusion time^b
14	5.9	1239	1239	28
15	5.1	1220	1224	25
16	4.5	1204	1224	24
17	3.9	1186	1193	22

^a Average number of patients per center for every step in the stepped-wedge design
^b Inclusion time in months including 4 weeks wash-in phase

ISSN: 1745-6215