Event | Presentation until start of iloprost or NaCl 0.9% | d1 | d2 | d3 | d4 | d5 | d6–d27 | Hospital discharge or d28 | Hospital discharge or d90 | d180 ± 14d |
---|---|---|---|---|---|---|---|---|---|---|
Informed consent | X | |||||||||
Inclusion/exclusion criteria | X | |||||||||
Pregnancy test in women of childbearing age | X | |||||||||
Demographics | X | |||||||||
Medical history | X | |||||||||
Randomization | X | |||||||||
Iloprost or NaCl 0.9% (control) | X | X | X | X | X | |||||
Clinical assessment including outcome | X | X | X | X | X | X | X | X | X | |
Laboratory testing | X | X | X | X | X | X | X | X | ||
Adverse/serious adverse event monitoring | X | X | X | X | X | X | X | |||
Plasma biomarkers | X | X | X | X | X | X | ||||
Barthel Index | X | X | X | X | ||||||
SOFA score | X | X | X | X | X | X | X | X | ||
Health-related questionnaire | X | |||||||||
VES | X |