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Table 3 Overview of the study visits

From: A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome

 Screening visitBaseline visitTreatment visits (16 weeks)End-of-treatment visitPregnancy visit
Personalized acupunctureFixed acupunctureLetrozolePlacebo letrozole
Sign consent×       
History×     × 
Urine pregnancy test××××××  
Physical examination×     × 
Transvaginal ultrasound×      ×
Semen analysis×       
Tubal patency test×       
HPV or TCT×       
Preconception counseling×       
Fasting blood for laboratory tests×     × 
Blood sample collection ×    × 
Serum progesterone assay× ×××× ×
Serum HCG assay×××××× ×
Questionnaires ×    × 
Acupuncture treatment (three times weekly)  ××    
Assess adverse events and concomitant medications  ××××××
Pregnancy and neonatal records       ×
  1. Physical examination: weight, height, waist circumference, hip circumference, Ferriman-Gallwey/acne
  2. Fasting blood for laboratory test: follicle-stimulating hormone, luteinizing hormone, sex hormone–binding globulin, total testosterone, free testosterone, estradiol, prolactin, fasting blood glucose, fasting insulin, C-peptide, glycated hemoglobin, cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, complete blood count, thyroid profile, renal profile, and liver profile
  3. Transvaginal ultrasound: endometrial thickness, ovarian volume, antral follicle count, and size of ovarian cysts or developing follicles
  4. Preconception counseling: TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpesvirus) and human immunodeficiency virus screening
  5. Blood sample collection: serum for the central core laboratory
  6. Abbreviations: HCG Human chorionic gonadotropin, HPV Human papillomavirus, TCT ThinPrep cytologic test