Study endpoint | Description | Data source |
---|---|---|
Primary endpoints | ||
 Case notification rates (cases notified per 10,000 population per year) | Numerator: number of cases notified by the selected districts | Case notification data from CENAT |
Denominator: total population in the OD | Population statistics (Ministry of Planning/Department of Statistics/CENAT) | |
 Additionality (additional number of cases reported compared to historical baseline) | Number of cases notified by the selected districts | Case notification data from CENAT |
Historical data (cases notified in the preceding 3 years) | Historical case notification data from CENAT | |
 Cumulative yield (cases diagnosed per 1000 screened) | Numerator: number of cases reported by each arm | Program data In the control arm, data to be collected from the health centers monthly |
Denominator: total number of individuals screened | Program data Provincial health department laboratory data to determine the number of people screened at health centers in the control arm | |
Secondary endpoints | ||
 Treatment outcomes | TB treatment outcomes of all new patients 6 months after treatment initiation | Health centers |
 Number needed to screen | Numerator: total number of individuals screened | Program data Provincial health department laboratory data to determine the number of people screened at health centers in the control arm |
Denominator: number of cases reported by each arm | Program data Control arm: data to be collected from the health centers monthly | |
 Cost per TB case diagnosed/notified | Direct and indirect medical costs while seeking care for TB Staff and intervention costs Diagnostics and medication costs | Health-care-seeking costs: data to be collected in the baseline and follow-up survey Intervention costs: data to be collected from KHANA, CENAT, and CATA DALYs: data to be extracted from WHO global burden of disease studies and other existing literature |
 Incremental cost-effectiveness ratio per DALY averted |