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Table 1 Nasal Airway Obstruction Study (NAIROS) eligibility criteria

From: Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction

Inclusion criteriaExclusion criteria
• Adults aged ≥ 18 years
• Baseline NOSE score ≥ 30
• Septal deflection at baseline visible via nasendoscopy
• Capacity and willingness to provide written informed consent and complete the trial questionnaires
• Any prior septal surgery
• Systemic inflammatory disease or the use of any current oral steroid treatment within the past 2 weeks
• Granulomatosis with polyangiitis
• Nasendoscopic evidence of unrelated associated pathology, e.g. adenoid pad, septal perforation, chronic rhinosinusitis indicated by the presence of polyposis or pus
• Any history of intranasal recreational drug use within the past 6 months
• Breast-feeding, pregnancy or intended pregnancy for the duration of involvement in the trial
• Bleeding diathesis
• Therapeutic anticoagulation (warfarin/novel oral anti-coagulant (NOAC) therapy)
• Clinically significant contraindication to general anaesthesia
• Patients known to be immuno-compromised
• Those in whom an external bony deformity substantially contributes to the nasal obstruction